Literature summary extracted from
Wang, Y.; Su, G.H.; Zhang, F.; Chu, J.X.; Wang, Y.S.
Cyclic GMP-AMP synthase is required for cell proliferation and inflammatory responses in rheumatoid arthritis synoviocytes (2015), Mediators Inflamm., 2015, 192329.
Application
EC Number |
Application |
Comment |
Organism |
---|
2.7.7.86 |
medicine |
cGAS activates the AKT and ERK pathways to promote the inflammatory response of rheumatoid arthritis fibroblast-like synoviocytes |
Homo sapiens |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.7.86 |
Homo sapiens |
Q8N884 |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
2.7.7.86 |
synoviocyte |
rheumatoid arthritis synoviocyte |
Homo sapiens |
- |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.7.7.86 |
physiological function |
cGAS is overexpressed in rheumatoid arthritis fibroblast-like synoviocytes compared with osteoarthritis fibroblast-like synoviocytes. TNFalpha stimulation induces cGAS expression in rheumatoid arthritis fibroblast-like synoviocytes. Overexpression of cGAS promotes the proliferation and knockdown of cGAS inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes. cGAS overexpression enhances the production of proinflammatory cytokines and matrix metalloproteinases as well as AKT and ERK phosphorylation in TNFalpha-stimulated fibroblast-like synoviocytes. In contrast, cGAS silencing inhibits production of proinflammatory cytokines and matrix metalloproteinases as well as AKT and ERK phosphorylation in TNFalpha-stimulated fibroblast-like synoviocytes |
Homo sapiens |