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Literature summary extracted from

  • Wang, Y.; Su, G.H.; Zhang, F.; Chu, J.X.; Wang, Y.S.
    Cyclic GMP-AMP synthase is required for cell proliferation and inflammatory responses in rheumatoid arthritis synoviocytes (2015), Mediators Inflamm., 2015, 192329.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.7.86 medicine cGAS activates the AKT and ERK pathways to promote the inflammatory response of rheumatoid arthritis fibroblast-like synoviocytes Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.86 Homo sapiens Q8N884
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.86 synoviocyte rheumatoid arthritis synoviocyte Homo sapiens
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General Information

EC Number General Information Comment Organism
2.7.7.86 physiological function cGAS is overexpressed in rheumatoid arthritis fibroblast-like synoviocytes compared with osteoarthritis fibroblast-like synoviocytes. TNFalpha stimulation induces cGAS expression in rheumatoid arthritis fibroblast-like synoviocytes. Overexpression of cGAS promotes the proliferation and knockdown of cGAS inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes. cGAS overexpression enhances the production of proinflammatory cytokines and matrix metalloproteinases as well as AKT and ERK phosphorylation in TNFalpha-stimulated fibroblast-like synoviocytes. In contrast, cGAS silencing inhibits production of proinflammatory cytokines and matrix metalloproteinases as well as AKT and ERK phosphorylation in TNFalpha-stimulated fibroblast-like synoviocytes Homo sapiens